A acadêmica Gabriela Parchen publicou na revista internacional, Journal of Pharmaceutical Sciences da Elsevier (fator de impacto 3,2). No trabalho, realizado pela acadêmica do BIOPOL, foram desenvolvidos sistemas nanométricos inteligentes para liberação de fator de crescimento epidermal. Tais sistemas modulam a permeação do EGF na pele e são responsivos à condição inflamatória cutânea. Co-autores do trabalho: Joslaine Jacumazo, Heidegrid Siebert Koop, Stellee Marcela Petris Biscaia, Edvaldo S. Trindade, Joana Léa Meira Silveira e Rilton Alves de Freitas. O artigo pode ser acessado no seguinte link.
Abstract
This work describes the development of polysaccharide-coated liposomes to modulate the delivery of epidermal growth factor (EGF), with the aim to produce different EGF release profiles depending on the milieu of infected wounds. For this purpose, cationic liposomes were coated with one layer of sodium alginate (ALG) followed by one layer of chitosan (CHI) using the layer-by-layer (LbL) technique. The coated liposomes exhibited apparent hydrodynamic diameters of 278 ± 36 and 216 ± 96 nm for Lip-ALG and Lip-ALG-CHI, respectively. Thus, it appears that adding the CHI layer compacted the Lip-ALG one. The incorporation efficiency of EGF was a maximum of 55% for liposomes with a polymeric coating. In vitro release experiments showed that Lip-ALG-CHI exhibits a higher release rate constant under acidic pH conditions, resembling those of infected tissue. Using an ex vivo model of EGF release in porcine ear skin, these liposomes were found to accumulate in the epidermis. Thus, coated liposomes could represent a local EGF delivery mechanism to promote healing.